Development of a novel, concentric micro-ECoG array enabling simultaneous detection of a single location by multiple electrode sizes.
Biomedical physics & engineering express(2024)
摘要
OBJECTIVE:Detection of the epileptogenic zone is critical, especially for patients with
drug-resistant epilepsy. Accurately mapping cortical regions exhibiting high activity during
spontaneous seizure events while detecting neural activity up to 500 Hz can assist clinicians'
surgical decisions and improve patient outcomes.
APPROACH:We designed, fabricated,
and tested a novel hybrid, multi-scale micro-electrocorticography (micro-ECoG) array with
a unique embedded configuration. This array was compared to a commercially available
microelectrode array (Neuronexus) for recording neural activity in rodent sensory cortex
elicited by somatosensory evoked potentials and pilocarpine-induced seizures. Main results
Evoked potentials and spatial maps recorded by the multi-scale array ("micros", "mesos", and
"macros" refering to the relative electrode sizes, 40 micron, 1 mm, and 4 mm respectively)
were comparable to the Neuronexus array. The SSEPs recorded with the micros had higher
peak amplitudes and greater signal power than those recorded by the larger mesos and macro.
Seizure onset events and high-frequency oscillations (∼450 Hz) were detected on the multi-
scale, similar to the commercially available array. The micros had greater SNR than the mesos
and macro over the 5-1000 Hz frequency range during seizure monitoring. During cortical
stimulation experimentation, the mesos successfully elicited motor effects.
SIGNIFICANCE:
Previous studies have compared macro- and microelectrodes for localizing seizure activity in
adjacent regions. The multi-scale design validated here is the first to simultaneously measure
macro- and microelectrode signals from the same overlapping cortical area. This enables direct
comparison of microelectrode recordings to the macroelectrode recordings used in standard
neurosurgical practice. Previous studies have also shown that cortical regions generating
high-frequency oscillations are at an increased risk for becoming epileptogenic zones. More
accurate mapping of these micro seizures may improve surgical outcomes for epilepsy patients.
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