Estimation the Effect of Ficus carica Active components’ Nanoparticles on Mice Infected by Schistosomal cercariae and treated with praziquantel

Abstract Bilharzia is parasitic flatworm that causes schistosomiasis, a neglected tropical illness of worldwide. Praziquantel (PZQ) is a commercial single treatment of schistosomiasis so the alternative drugs are needed to get rid of its side effects on liver. The current study aimed to estimate the effective role of Ficus carica nanoparticles (Fc-NPCs), silver nanoparticles (Ag-NPCs) and Ficus carica nanoparticles loaded on silver nanoparticles (Fc-Ag NPCs) on C57BL/6 black female mice infected by Schistosoma mansoni and treated with PZQ treatment. It was proved that the schistosomiasis causes liver damage in addition to the PZQ is ineffective as anti-schistosomiasis; it is recorded in infected mice group and PZQ treated group as in liver function tests, oxidative stress markers & anti-oxidants, pro-inflammatory markers, pro-apoptotic and anti-apoptotic markers also in liver cells’ DNA damage. The amelioration in all tested parameters has been clarified in nanoparticles’ protected mice groups. Obviously, The Fc-Ag NPCs + PZQ group recorded the best preemptive effects as anti-schistosomiasis. Fc-NPCs, Ag-NPCs and Fc-Ag NPCs could antagonize PZQ effects that were observed in amelioration of all tested parameters. The study showed the phytochemicals’ nanoparticles groups have ameliorated effect on the health of infected-administered mice.