Characteristics and Bioactivities of Carrageenan/Chitosan Microparticles Loading α-Mangostin

This study attempted to develop carrageenan/chitosan based microparticles loading α-mangostin which was extracted from Vietnamese mangosteen skin. The carrageenan/chitosan/α-mangostin microparticles were prepared by ionic gelation method by mixing chitosan, carrageenan with α-mangostin and subsequently cross-linking the mixtures with sodium tripolyphosphate crosslinking agent. The content of α-mangostin in microparticles was changed to evaluate the effect of α-mangostin content on physical, morphological properties, particles size and bioactivities of the carrageenan/chitosan/α-mangostin microparticles. The obtained results showed that carrageenan, chitosan was interacted together and with α-mangostin. The presence of polymers matrix improved the release ability of α-mangostin into ethanol/pH buffer solutions. The carrageenan/chitosan/α-mangostin microparticles have antibacterial (gram ( +) strains) and antioxidant activities. The results suggested that combination of chitosan and carrageenan in the microparticles can enhance the control release of α-mangostin into solutions as well as keep the bioactivities and reduce the vero cell toxicity of α-mangostin.