Gut microbiota, blood metabolites, and left ventricular diastolic dysfunction in US Hispanics/Latinos

Left ventricular diastolic dysfunction (LVDD) is an important precursor of heart failure (HF), but little is known about its relationship with gut dysbiosis and microbial-related metabolites. By leveraging the multi-omics data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a study with population at high burden of LVDD, we aimed to characterize gut microbiota associated with LVDD and identify metabolite signatures of gut dysbiosis and incident LVDD. We included up to 1996 Hispanic/Latino adults (mean age: 59.4 years; 67.1