Nicotine exacerbates liver damage in a mice model of Ehrlich ascites carcinoma through shifting SOD/NF-κB/caspase-3 pathways: ameliorating role of Chlorella vulgaris

Ehsan H. Abu-Zeid, Eman W. El-Hady, Gehan A. Ahmed,Yasmina M. Abd-Elhakim,Doaa Ibrahim,Noura A. Abd-Allah,Ahmed H. Arisha,Mohammed S. Sobh,Azza M. A. Abo-Elmaaty

Naunyn-Schmiedeberg's Archives of Pharmacology（2024）

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Abstract

Nicotine, a pervasive global environmental pollutant, is released throughout every phase of the tobacco’s life cycle. This study examined the probable ameliorative role of Chlorella vulgaris (ChV) extract against nicotine (NIC)-induced hepatic injury in Ehrlich ascites carcinoma (EAC) bearing female Swiss mice. Sixty female Swiss mice were assigned to four equal groups orally gavaged 2

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Key words

Nicotine,Chlorella vulgaris,Hepatotoxicity,Ehrlich’s ascites carcinoma,Nuclear Factor-kappa β NF-κB,Oxidative stress

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