A Novel Polyp Retrieval Bag Reduces the Polyp Fragmentation Rate in Colon Polypectomy : A Single-Blind Randomized Controlled Study

Abstract Purpose The fragmentation of polyps affects complete resection confirmation. The primary aim of this study was to assess the feasibility of a novel polyp retrieval bag for reducing the fragmentation rate of colon polyps. Methods Patients with a 5–15 mm colon polyp were recruited and randomized to two groups at a 1:1 ratio. After polyp resection, polyps obtained from patients in the treatment group were extracted using a novel polyp retrieval bag without traversing the instrument channel, while polyps obtained from patients in the control group were collected by traversing the instrument channel, attaching the polyp trap to the instrument channel port and applying suction. Results From January to July, 2022, a total of 225 patients were assessed for study eligibility. A total of 204 patients were enrolled in the study, and seven patients with specimen retrieval failure were excluded from the analysis. The polyp fragmentation rate in the treatment group was significantly lower than that in the control group (3.0% [3/100] vs. 17.5% [17/97], P = 0.001). There was no significant difference in the retrieval failure rates between the treatment group and control group (2.0% [2/102] vs. 4.9% [5/102], P = 0.442). There were fewer colonoscope insertions in the treatment group than in the control group (102 vs. 110), but a significant difference was not present (P = 0.065). No significant adverse events were observed in the follow-up. Conclusions This study demonstrated that the polyp retrieval bag was safe and feasible for reducing the fragmentation rate of retrieved polyps. Trial registration: The study was registered at ClinicalTrials.gov ( NCT05189912, 1/12/2021).