CdS quantum dots sensitized Ti-MOFs as high-performance photocathodic materials for immunoassay of alpha-fetoprotein based on Ag plus exchange strategy
JOURNAL OF ELECTROANALYTICAL CHEMISTRY(2024)
Abstract
Cathodic photoelectrochemical (PEC) analysis has drawn much attention because of its excellent antiinterference capability toward reductive substances in samples, but the development high-performance photocathodic materials is challenging. We report here CdS quantum dots (QDs) sensitized titanium-based metal-organic frameworks (Ti-MOFs) as high-performance photocathodic materials for ultrasensitive immunoassay of alpha-fetoprotein (AFP) based on Ag+ exchange strategy. Due to the excellent sensitization effect of CdS QDs, the photocathodic current of CdS QDs decorated MIL-125-NH2(Ti) is 25-fold that of MIL-125-NH2(Ti) alone. The photocathodic current of CdS/MIL-125-NH2(Ti) can be quenched after Ag+ exchange, because CdS is partially converted to Ag2S that serves as a charge-recombination center. Based on the PEC response of CdS/MIL-125NH2(Ti) to Ag+, a cathodic PEC immunoassay platform is constructed for AFP detection by using CdS/MIL-125NH2(Ti) as the photoactive material and Ag nanoparticles modified SiO2 nanospheres as labels. The linear range for AFP detection is from 1.0 x 10-4 to 1.0 x 102 ng mL-1, and the detection limit is 20 fg mL-1. The constructed PEC immunosensor is successfully used for detecting AFP in human serum samples. In this work, a novel and high-performance photoactive material is developed for cathodic PEC analysis, and a simple and effective PEC immunoassay platform for AFP detection is constructed based on Ag+ exchange strategy.
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Key words
Titanium-based metal -organic frameworks,CdS quantum dots,Photoelectrochemical analysis,Alpha-fetoprotein,Ag plus exchange
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