Prognostic Values of Inflammatory Markers in Patients with High-grade Lamina Propria-invasive Bladder Cancer

Objective: In this study, we investigated the prognostic values of various pathological and inflammatory parameters in patients with high-grade lamina propriainvasive (T1G3) bladder cancer (BC). Materials and Methods: Between 2006 and 2018, patients with pathological evaluation of T1G3 bladder urothelial carcinoma in our institution who did not meet the exclusion criteria were included in the study. Parameters such as gender, tumor diameter, tumor number, lamina propria invasion depth, presence of carcinoma in situ, presence of lymphovascular invasion (LVI), presence of variant histology, lymphocyte monocyte ratio (LMR), platelet lymphocyte ratio (PLR), neutrophil lymphocyte ratio (NLR), and systemic inflammatory markers (SIM) were statistically analyzed. Results: After the exclusion criteria were evaluated, 76 patients were included in the study from 157 patients. Recurrence was observed in 37 (48.68%) patients, and progression was observed in 21 (27.63%) patients. A significant relationship was discovered between LMR (p<0,001), PLR (p<0.004), NLR (p<0.002), tumor diameter (p<0.002), number of tumors (p<0,007), and SIM score (p<0,001) with the probability of recurrence. The probability of progression was associated with NLR (p<0.023), LVI (p<0.005), tumor diameter (p<0.012) and tumor number (p<0.001). A significant relationship was found between SIM (p<0.041) and recurrencefree survival. We found a significant relationship between LVI (p<0.022) and progression -free survival. Conclusions: In this study, we found positive correlations between some inflammatory markers and recurrence/progression in patients with T1G3 BC. According to our study, inflammatory parameters such as NLR, PLR, LMR, and SIM score should be evaluated while investigating the possibility of recurrence/progression in patients with T1G3 BC.