Biphenotypic lung carcinoma with coexpression of TTF-1 and NP63/P40 within most of the same individual cells: a further case confirming poor prognosis and a review of literature

The WHO Classification of Tumors, Thoracic Tumors, 5th edition, has outlined the use of TTF-1 and Delta NP63/P40 to discriminate between adenocarcinoma and squamous cell carcinoma. In 2015, the first description of a rare non-small cell lung carcinoma featuring coexpression of glandular and squamous differentiation within most of the same individual tumor cells was reported on, with ultrastructural and molecular demonstration of such a biphenotypic differentiation. We herein describe an additional case of this rare tumor entity, which is confirmed to be an aggressive neoplasm despite potential targets of therapy.