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Peptide nanovaccine conjugated via retro-Diels-Alder reaction linker for overcoming the obstacle in lymph node penetration and eliciting robust cellular immunity

Kuncheng Lv,Sheng Ma, Liping Liu,Hongyu Chen,Zichao Huang, Zhenyi Zhu, Yibo Qi,Wantong Song

Journal of Materials Chemistry B（2024）

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Abstract
Nanoparticles have been regarded as a promising vaccine adjuvant due to their innate immune potentiation and enhanced antigen transport. However, the inefficient infiltration into the lymph node (LN) paracortex of...
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