Rosavin improves insulin resistance and alleviates hepatic and kidney damage via modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals

Hebatallah S. Ali,Hiba S. Al-Amodi,Shaimaa Hamady, Marian M. S. Roushdy,Amany Helmy Hasanin, Ghada Ellithy,Rasha A. Elmansy, Hagir H. T. Ahmed, Enshrah M. E. Ahmed, Doaa M. A. Elzoghby,Hala F. M. Kamel, Ghida Hassan,Hind A. ELsawi,Laila M. Farid,Mariam B. Abouelkhair,Eman K. Habib, Mohamed Elesawi,Heba Fikry,Lobna A. Saleh,Marwa Matboli

RSC Medicinal Chemistry（2024）

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摘要

Background: Inflammation-mediated insulin resistance in type 2 diabetes mellitus (T2DM) increases complications, necessitating investigation of its mechanism to find new safe therapies.

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