Anti-PD-1 alone or in combination with anti-CTLA-4 for advanced melanoma patients with liver metastases.
European Journal of Cancer(2024)
Abstract
Background
The combination of anti-PD-1 and anti-CTLA-4 has been associated with improvement in response and survival over anti-PD-1 monotherapy in unselected patients with advanced melanoma. Whether patients with liver metastases also benefit from the combination of anti-PD-1 and anti-CTLA-4 over anti-PD-1, is unclear. In this study, we sought to assess whether the combination of anti-PD-1 and anti-CTLA-4 leads to better response, progression-free survival and overall survival, compared with anti-PD-1 monotherapy for patients with liver metastases.
Methods
We have conducted an international multicentre retrospective study. Patients with advanced melanoma with liver metastases treated with 1st line anti-PD1 monotherapy or with anti-CTLA-4 were included. The endpoints of this study were: objective response rate, progression-free survival and overall survival.
Results
With a median follow-up from commencement of anti-PD-1 monotherapy or in combination with anti-CTLA-4 of 47 months (95% CI, 42–51), objective response rate was higher with combination therapy (47%) versus anti-PD-1 monotherapy (35%) (p=0.0027), while progression-free survival and overall survival were not statistically different between both treatment groups. However, on multivariable analysis with multiple imputation for missing values and adjusting for predefined variables, combination of anti-PD1 and anti-CTLA-4 was associated with higher objective response (OR 2.21, 1.46 – 3.36; p<0.001), progression-free survival (HR 0.73, 0.57 – 0.92; p=0.009) and overall survival (HR 0.71, 0.54 – 0.94; p=0.018) compared to anti-PD1 monotherapy.
Conclusions
Findings from this study will help guide treatment selection for patients who present with liver metastases, suggesting that combination therapy should be considered for this group of patients.
MoreTranslated text
Key words
advanced melanoma","metastatic melanoma",“anti-CTLA-4”,“anti-PD-(L)1”,“immunotherapy”,“combination immunotherapy”,“liver metastases”
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined