Neuroinflammation is associated with Alzheimer’s disease co-pathology in dementia with Lewy bodies

Janna van Wetering, Hanne Geut, John J. Bol, Yvon Galis, Evelien Timmermans,Jos W.R. Twisk,Dagmar H. Hepp, Martino L. Morella,Lasse Pihlstrom,Afina W. Lemstra,Annemieke J.M. Rozemuller,Laura E. Jonkman,Wilma D.J. van de Berg

Acta Neuropathologica Communications（2024）

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摘要

Neuroinflammation and Alzheimer’s disease (AD) co-pathology may contribute to disease progression and severity in dementia with Lewy bodies (DLB). This study aims to clarify whether a different pattern of neuroinflammation, such as alteration in microglial and astroglial morphology and distribution, is present in DLB cases with and without AD co-pathology. The morphology and load (

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关键词

Lewy body disease,Dementia with Lewy bodies,Alzheimer’s disease,Co-pathology,Neuroinflammation,Alpha-synuclein,Amyloid-beta,Phosphorylated-tau,Microglia,Astroglia,Post-mortem,Immunohistochemistry

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