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Persistence of Treponema pallidum IgM antibodies in serum: what is their meaning?

Giulia Ciccarese,Elisabetta Capello,Serena Varesano,Lorenzo Giacani,Niccolò Capurro,Francesco Drago

Diagnostic Microbiology and Infectious Disease（2024）

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Abstract
We studied the detection of Treponema pallidum (TP)-IgM antibodies in the serum of 69 patients treated for syphilis. The persistence of TP-IgM antibodies in serum for more than 3 years was the only clue to suspect an active infection and, therefore, to investigate a central nervous system involvement.
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Key words
Syphilis,Treponema pallidum IgM antibodies,neurosyphilis
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