基于脂质组学研究胡椒碱对肥胖大鼠脂代谢基因昼夜节律的影响
Food Science(2024)
Abstract
采用高脂饮食(high fat diet,HFD)诱导的肥胖大鼠模型,探究口服胡椒碱(1-piperoylpiperidine,PIP)对代谢紊乱引发生物钟异常的调控作用.结果表明,PIP减轻了HFD诱导的肝脏损伤,降低了血脂水平,缓解了肝脏生物钟和脂代谢基因的昼夜节律紊乱,恢复了与生物钟密切相关的脂质分子溶血磷脂酸(16∶0_18∶1)、双甲基磷脂酸(38∶8e)、磷脂酰乙醇胺(16∶0p_22∶6)和甲基磷胆碱(32∶4e)的表达水平变化.本研究结果可为PIP调节肝脏脂代谢昼夜节律提供一定的理论依据.
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Key words
piperine,obese rats,lipid metabolism,circadian rhythm
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