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Evaluation of Posaconazole Serum Concentrations Achieved With Delayed-release Tablets and Oral Suspension in Patients Undergoing Intensive Chemotherapy for Acute Myeloid Leukemia and Myelodysplastic Syndrome

Leonora Muehlberg, Thomas Pabst, Carlo Largiader, Yolanda Aebi, Michael Hayoz, Konrad Muehlethaler, Stefan Zimmerli, Cedric Hirzel

OPEN FORUM INFECTIOUS DISEASES（2024）

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Abstract
Data on posaconazole serum levels of patients on prophylaxis with delayed-release tablets or oral suspension during intensive chemotherapy for acute myeloid leukemia and myelodysplastic syndrome are scarce. In this analysis, the proportion of patients with acute myeloid leukemia/myelodysplastic syndrome achieving posaconazole target concentrations with delayed-release tablets was higher than with oral suspension.
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Key words
acute myeloid leukemia,intensive chemotherapy,myelodysplastic syndrome,posaconazole prophylaxis
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