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Granulomatous Meningoencephalitis and Blindness Associated with Mycobacterium Tuberculosis Complex Infection in a Senile Female Chimpanzee (pan Troglodytes)

Daniel Oliveira dos Santos,Nayara Ferreira de Paula,Thaynara Parente de Carvalho,Lucas dos Reis de Souza,Herlandes Penha Tinoco,Carlyle Mendes Coelho, Ana Augusta Sousa,Paulo Martins Soares Filho, Luciana Rabello Ferreira,Tatiane Alves da Paixao,Ayisa Rodrigues Oliveira,Renato Lima Santos

Journal of medical primatology（2024）

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Abstract
A 40-year old female chimpanzee (Pan troglodytes) developed hyporexia, weight loss, followed by progressive and complete blindness. Tomography demonstrated an intracranial mass in the rostroventral brain involving the optic chiasm, with a presumptive diagnosis of neoplasm. However, histopathology revealed a granulomatous meningoencephalitis, and tissue samples tested positive for Mycobacterium tuberculosis.
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Key words
blindness,encephalitis,meningitis,mycobacteriosis,tuberculosis
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