Development of an Active Surface Fabricated by Embedded Amoxicillin in an Acrylate Coating and Soluble Soybean Polysaccharide

In this experimental research, the fabrication of a novel active surface with improved antimicrobial functionality has been pioneered using imprinting technology. In this regard, Amoxicillin acrylate (Ac) coating was applied on soluble soybean polysaccharide (SSPS) film by cold plasma. The physicochemical constituents of the films were examined by FTIR, DMTA, and X-ray diffraction analyses both before and after coating. Results revealed that the chemical structure of the SSPS film did not alter after coating with Ac. Moreover, the cross-section image of the film, obtained by SEM, showed that the SSPS-Ac layer was smooth. The crystalline peaks of the Amoxicillin were not observed in the XRD pattern of the film, demonstrating the destruction of the crystalline structure of Amoxicillin. The loss modulus diagram for the SSPS-Ac sample showed a peak at the temperature range of − 70 to − 34 °C, which was related to the glass transition temperature. The coating could inhibit the growth of Staphylococcus aureus. These results revealed the great potential of imprinting technology for the fabrication of active surfaces to achieve diverse functionalities such as disinfection of hospital equipment.