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Effects of crotamine in human prostate cancer cell line

Joao Victor Alberghini-dos-Santos, Caroline Andolfato Sanchez,Karla de Castro Figueiredo Bordon,Manuela Berto Pucca,Lusania Maria Greggi Antunes,Eliane Candiani Arantes,Isadora Sousa de Oliveira

TOXICON（2024）

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Abstract
Our study presents the anticancer potential of crotamine from Crotalus durissus terrificus in human prostate cancer cell line DU-145. Crotamine isolation was conducted through RP-FPLC, its molecular mass analyzed by MALDITOF was 4881.4 kDa, and N-terminal sequencing confirmed crotamine identity. Crotamine demonstrated no toxicity and did not inhibit migration in HUVEC cells. Although no cell death occurred in DU-145 cells, crotamine inhibited their migration. Thus, crotamine presented potential to be a prototype of anticancer drug.
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Key words
Snake venoms,Crotalus durissus terrificus,Anticancer,CPP,DU-145
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