Preparation and Physicochemical Properties of a Thermosensitive Hydrogel-based Lipopeptide Biosurfactant

Letters in Drug Design & Discovery(2024)

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摘要
Background: Temperature-sensitive (thermo-sensitive) formulations are a novel drug delivery dosage form that shows bio-inspired behavior in various applications. The structure and properties of a thermosensitive polymer are critical in designing an intelligent biometric polymer that contains lipopeptide biosurfactants. Objectives: In this study, thermo-sensitive hydrogels with lipopeptide biosurfactants as a potential wound dressing dosage form were formulated and examined regarding physicochemical properties. Methods: The lipopeptide biosurfactants were isolated from the Acinetobacter junni B6 bacterial strain and loaded on a formulation of poloxamer 407® and carboxymethyl cellulose as a gelling agent. Numerous experiments were carried out to evaluate the physicochemical properties of these formulations, such as the stability, spreadability, release profile, and kinetic. Results: The formulation (Poloxamer 407® (19% w/v), carboxymethyl cellulose (2% w/v), lipopeptide biosurfactants (5mg/mL), benzyl alcohol (1% v/v), and 0.1mL polyethylene glycol 400) was select as the optimum formulation. The selected formulation released 26.9% of the lipopeptide biosurfactants with anomalous transport kinetics after 10 hours. Conclusions: The results showed that a thermo-sensitive formulation could help achieve a sustained release of lipopeptide biosurfactants and potentially be used as a dressing formulation for wounds in future studies.
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