Multicenter evaluation of Multi-Incision Technique (MIT) with Malleable Prosthesis in Peyronie's Disease in patients with or without preoperative Erectile Dysfunction

Abstract Penile length loss is a significant concern for Peyronie's Disease (PD) patients. Our main goal is to evaluate the use of the multi-incision corporal technique (MIT) with a malleable prosthesis and collagen sealant matrix graft in PD patients experiencing a severe penile length loss, regardless of preoperative erectile dysfunction (ED). We conducted a multicenter retrospective analysis in three centers from October 2015 to November 2021. Patients were divided into two groups: with or without preoperative ED. Data from 50 patients were collected, with 15 (30%) having preoperative normal erectile function. At a median follow-up of 17.6 months, 44/44 (100%) patients reported the ability to achieve penetration during sexual intercourse and no significant postoperative residual curvature. The mean increase in erectile penile length was 2.76 ± 0.63, with 85% of patients reporting a “very much” or “much better” improvement. Six grade IIIb postoperative complications were recorded. No significant differences in postoperative outcomes and global satisfaction scores were found between the two groups. MIT with malleable prosthesis and collagen sealant matrix graft is an effective long-term lengthening strategy with high global satisfaction rates in PD patients with complaints of penile length loss, even in those with preoperative normal erectile function.