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Synthesis of (S)-N-Ethyl-2-(5-methylidene-4-oxocyclopent-2-en-1-yl)acetamide―A Model exo-Methylidenecyclopentenone Bioisoster of Prostamides

A. M. Gimazetdinov,Z. R. Makaev,M. S. Miftakhov

Russian Journal of Organic Chemistry（2024）

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Abstract
exo-Methylidenecyclopentenonee amide is synthesized from methyl 2-[((1R,2R,5R)-2-[(tert-butyl(dimethyl)silyl]oxymethyl)-5-(trimethylsilyl)cyclopent-3-en-1-yl]acetate.
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allylsilanes,bicyclic δ-lactones,cross-coupled cyclopentenones,prostamides
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