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靶向T细胞免疫治疗急性髓性白血病的策略

Cancer Research on Prevention and Treatment(2024)

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Abstract
急性髓性白血病(AML)常伴有T细胞免疫功能不全,由于免疫检查点(IC)分子表达上调引起T细胞耗竭是其重要原因之一.利用IC抑制剂治疗AML有一定的临床效果,但患者T细胞耗竭的异质性很大,且还存在其他原因引起的T细胞免疫功能不全,多层面分析区分不同类型的免疫缺陷而采取相应的靶向T细胞免疫治疗才是理想的策略.
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Key words
Acute myeloid leukemia,T cell,Exhaustion,Immune checkpoint protein,Immunotherapy
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