Evolution, control and success of combination therapy with Ampicilin-sulbactam/Ceftazidime-Avibactam during a Carbapenem-Resistant Acinetobacter baumannii outbreak in burn Intensive Care Unit

Emmanuel Dudoignon,Francois Caméléna,Matthieu Lafaurie,Benjamin Deniau,Maité Chaussard,Maxime Coutrot,Lucie Guillemet,Alexandru Cupaciu, Alexandre Pharaboz,Louis Boutin,Mourad Benyamina,Marc Chaouat,Maurice Mimoun,Manel Merimèche,Alexandre Mebazaa,Benoit Plaud,Béatrice Berçot,François Dépret, Guillaume Mellon

European Journal of Clinical Microbiology & Infectious Diseases（2024）

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摘要

We present our findings on interpatient transmission, epidemic control measures, and the outcomes of a series of ten critically ill burn patients who were either colonized or infected with carbapenem-resistant Acinetobacter baumannii (CRAB). None of the five infected patients achieved clinical cure, and all experienced relapses. Microbiological failure was observed in 40

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Carbapenem-resistant Acinetobacter baumannii,Burn,Outbreak,Whole-genome sequencing,Antibiotic resistance,Cefiderocol,Ampicillin-sulbactam

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