Spontaneous hemorrhage of peripheral neurofibroma in pregnancy: A case report

Introduction: Neurofibromas may grow in pregnancy due to hormonal sensitivity. This report describes a case of spontaneous hemorrhage from a neurofibroma in pregnancy. Case Report: A 27-year-old female with neurofibromatosis (NF1) presented at 30 weeks gestation with shortness of breath. Spontaneous hemorrhage was noted from her left leg neurofibroma. The patient underwent preprocedural fetal surveillance prior to proceeding with surgical debridement. Persistent fetal bradycardia was noted in setting of maternal hypotension with ongoing bleeding. An emergent cesarean delivery was performed and required debridement of the left thigh neurofibroma by the general surgical team. Conclusion: Spontaneous hemorrhage of neurofibromas is a rare, but reported complication. Neurofibromas may increase in size in pregnancy; however, spontaneous hemorrhage has not previously been documented to occur during pregnancy.