Palladium‐Catalyzed Allylation of Isocyanoacetates with Vinyl Aziridines

The first palladium‐catalyzed allylation of isocyanoacetates with vinyl aziridines has been developed. The reaction condition was suitable to a variety of α‐aryl isocyanoacetates as well as N‐substituted vinyl aziridines, affording the corresponding allylation products in moderate to high yields (up to 98%) along with excellent stereoselectivity and regioselectivity. The transformations of the allylation product into trans‐4,5‐dehydrolysine analogy and highly functionalized proline ester derivative were further demonstrated. In addition, preliminary asymmetric version has also been evaluated.