Microwave-assisted Method to Morpholinyl Analogue and Its Effect on Cadmium Tolerance of Soybean

A series of morpholiny analogues were efficiently obtained through nucleophilic aromatic substitution (SNAr) under microwave irradiation with simple operation. Furthermore, the molecular docking studies suggested that the compound 4m could bind receptor PYR1 much more strongly than abscisic acid. Significantly, the application of 4m could reduce the permeability of cell membranes to enhance the tolerance. Furthermore, the growth of root and above-ground parts and the fresh weight was improved when treatment with 4m under cadmium stress at 200–500 mg/L. Thus, compound 4m was successfully designed and synthesized as the most potent candidate.