Case report: Young onset stroke from familial hypercholesterolemia

Introduction. Familial hypercholesterolemia (FH) is a medical condition that leads to extremely high levels of low-density lipoprotein (LDL) cholesterol, increasing the risk of ischemic heart disease, including myocardial infarction. However, the link between FH and ischemic stroke is still debatable. In this case, we report the case of a young adult female who had FH and high levels of LDL and suffered from an early-onset ischemic stroke. Case presentation. A 38-year-old female presented with acute numbness and weakness in her right limb, as well as speech difficulty. She had no history of hypertension, migraine, or diabetes, but did have a history of eyelid xanthoma. The results of the neurological examination confirmed a slightly gradual response, a mild weakness in her right limb, and a slightly reduced response to touch and pain. Laboratory tests showed very high cholesterol and LDL levels, as well as an increased CRP level. Radiological examination via a CT scan revealed lesions within the left frontotemporal region. The patient was prescribed dual antiplatelet therapy and vascular risk factor medication, and after 6 days of treatment, was discharged to go home. Conclusion. We present a case of ischemic stroke in a young patient with clinically diagnosed FH, highlighting the possibility of FH in those with early-onset cerebrovascular disease.