One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline.
Beilstein journal of organic chemistry(2024)
摘要
A new method for the synthesis of heterocyclic systems containing tetrazole and tetrahydroisoquinoline is developed via the performance of one-pot Ugi-azide and Heck cyclization reactions. The integration of the multicomponent and post-condensation reactions in one-pot maximizes the pot-, atom-, and step-economy (PASE).
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关键词
heck reaction,one-pot,tetrahydroisoquinoline,tetrazolo-pyrazino[2,1-a]isoquinolin-6(5h)-ones,tetrazole,ugi-azide reaction
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