Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection

Genome Medicine(2024)

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Abstract
Gut dysbiosis has been linked with both HIV infection and diabetes, but its interplay with metabolic and inflammatory responses in diabetes, particularly in the context of HIV infection, remains unclear. We first conducted a cross-sectional association analysis to characterize the gut microbial, circulating metabolite, and immune/inflammatory protein features associated with diabetes in up to 493 women ( 146 with prevalent diabetes with 69.9
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Key words
HIV infection,Diabetes,Gut dysbiosis,Gut metagenome,Inflammatory proteome,Blood metabolome,Multi-omics integration
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