1081 A Randomized Controlled Trial of ISLEEP: Impact on Inpatient Disruption and Sleep

Abstract Introduction Hospitals often contribute to acute sleep deprivation in patients through modifiable disruptions. Although staff-directed interventions have proven beneficial, research exploring direct patient education and empowerment in reducing disruptions and enhancing inpatient sleep is lacking. Methods Patients were randomly assigned to either the I-SLEEP or standard care arm. Patients in the I-SLEEP arm received a 5-minute video emphasizing sleep hygiene and empowering them to advocate for reduced sleep disruptions. Both groups received a sleep kit. The Potential Sleep Disruptions Questionnaire measured patient-reported disruptions (vitals, tests, medications) and wrist actigraphy measured nightly sleep duration in minutes. Mixed-effects models, controlling for study day, age, gender, race, BMI, apnea risk, comorbidities (COPD or asthma, diabetes, chronic heart failure, end-stage renal disease), and subject random effects tested the effectiveness of I-SLEEP on outcomes. Results A total of 175 patients were randomized (95 I-SLEEP patients for 265 nights; 80 standard patients for 174 nights). Both groups were similar with respect to baseline characteristics. In unadjusted analyses, I-SLEEP patients reported fewer disruptions from vitals (63% vs. 74%), medications (49% vs. 60%), and tests (57% vs. 69%) compared to standard patients (p=0.02 for all). In adjusted analyses, I-SLEEP patients reported significantly lower odds of disruptions due to medications (OR 0.50 [0.27, 0.94], p=0.03) and tests (OR 0.44 [0.21, 0.91], p=0.026). In unadjusted analyses, although sleep duration was greater on I-SLEEP nights compared to standard nights (334 minutes vs. 309 minutes), this difference was not statistically significant (p=0.16). Adjusted analyses confirmed these results. However, an interaction between I-SLEEP and study night revealed that patients in I-SLEEP gained an additional 15 minutes of sleep per night during the intervention, although this difference was just shy of significance (p=0.06). Conclusion I-SLEEP is linked to decreased patient-reported sleep disruptions from medications and tests, and a trend towards greater objective inpatient sleep for each day in the intervention. Given the importance of improving sleep in hospitalized patients, I-SLEEP emerges as a patient-centered intervention with the potential to empower patients in advocating for improved sleep quality in the hospital. Support (if any) 1K24HL136859-05