Application of poly(Clove Oil)-Based Organo-Hydrogels for Drug Delivery Systems

Abstract Organo-hydrogels, which are polymeric and biocompatible materials, can control the rate of drug release and enable drugs to reach target sites easily. In the presented study, clove oil-based organo-hydrogels were synthesized for the first-time using agar(A), glycerol(G), and clove oil(ClO), which have biocompatible, antioxidant, and therapeutic properties, and were used as drug release support material for the first time. Gel(AG), hydrogel(p(AG-m) and p(AG-g)), and organo-hydrogels(p(AG-m-ClO) and p(AG-g-ClO) based) were synthesized by redox polymerization technique using N,N, methylenebisacrylamide(MBA) and glutaraldehyde(GA) crosslinkers. In addition, to observe the effect of the amount of clove oil, organo-hydrogels were synthesized with different oil ratios(between 0.1–0.3 mg).In this way were synthesized six different organo-hydrogels. Vitamin D and 5-Fluorouracil(5-Flu) were selected as model drugs. The structure of gel, hydrogel and organo-hydrogels cross-linked with MBA or GA reagent were elucidated by Fourier Transform Infrared Spectroscopy(FTIR),swelling analysis, blood coagulation, hemolysis analysis, and Antioxidant analysis. The FTIR results showed that the structure of Agar and Glycerol based gel and hydrogels was changed after adding clove oil. The results of blood clotting, hemolysis, and antioxidant analysis showed that the organo-hydrogels prepared were blood and biocompatible. The swelling analyses showed that varying amounts of clove oil affected the swelling capacity of organo-hydrogels. The slow-release properties and release kinetics(Zero-order kinetic(ZoKM),First-order kinetic(FoKM),Higuchi(HKM), and Korsmeyer-Peppas model(KPKM)) of organo-hydrogels as a function of pH were also investigated. The results showed that these new organo-hydrogels were not only blood compatible and biocompatible but also had good slow-release properties that can effectively improve the utilization of drugs.