Altered oral microbiome, but normal human papilloma virus prevalence in cartilage-hair hypoplasia patients
Orphanet Journal of Rare Diseases(2024)
Abstract
Cartilage-hair hypoplasia (CHH) is a rare syndromic immunodeficiency with metaphyseal chondrodysplasia and increased risk of malignancy. In this cross-sectional observational study, we examined HPV status and oral microbiome in individuals with CHH. Oral brush samples were collected from 20 individuals with CHH (aged 5–59 years) and 41 controls (1–69 years). Alpha HPVs (43 types) were tested by nested PCR followed by bead-based probe hybridization. Separately, beta-, gamma-, mu- and nu- HPV types were investigated, and a genome-based bacterial microbiome sequencing was performed. We found a similar alpha HPV prevalence in individuals with CHH (45
MoreTranslated text
Key words
Cartilage-hair hypoplasia,Inborn errors of immunity,Human papilloma virus,Microbiome
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined