Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner

Aikaterini Karagianni, Anastasia Iris Karkempetzaki,Daniel Brooks,Shinobu Matsuura, Vrinda Dambal,Philip C. Trackman,Katya Ravid

Blood（2024）

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摘要

Lysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone volume and collagen architecture in a sex-dependent manner.

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