Pathological Profile of the Carcinoma Breast Patients with Relation to Serum Prolactin Levels in an Apex Institute of Uttar Pradesh

Introduction: Breast cancer is most common cancer on females worldwide with high mortality. PRL (prolactin) has a role in mammary gland growth, differentiation and lactation. It has been revealed that PRL may be involved in pathogenesis and progression of breast cancer malignancy. This study was designed to find out any association between serum Prolactin level with breast cancer and in its various stages. In this article a comparative cross sectional study with 30 cases and 28 controls conducted in apex institute of Varanasi, U.P. from July 2016 to July 2018 has been done. The serum prolactin levels were determined by AxSYM system which is a micro-particle enzyme immunoassay (MEIA) technology. RESULTS: Early menarche and post-menopausal status are significantly more associated with Carcinoma breast. Most common associated history with carcinoma breast was anorexia and weight loss. Mean prolactin level was significantly higher in carcinoma breast patients (39.67±7.71) in comparison to controls (28.72±1.63). CONCLUSIONS: All high risk postmenopausal women with early age of menarche and not having breastfed should be made aware about breast cancer and train Self Breast Examination. Prolactin can be a potential target for primary prevention and intervention in breast cancer, especially in high risk females. Key words: breast cancer; prolactin; post-menopause;