Dupilumab treatment of trichothiodystrophy in a child
PEDIATRIC DERMATOLOGY(2024)
摘要
Trichothiodystrophy (TTD) is a rare congenital disorder caused by genetic mutations, leading to hair and skin abnormalities. We report successful treatment of a TTD case using dupilumab, a monoclonal antibody targeting IL-4R alpha. The patient, a 7-year-old boy, exhibited significant improvement in skin and hair conditions, suggesting the potential of dupilumab as a therapeutic option for TTD. Further research is needed to elucidate its mechanism and efficacy in TTD treatment.
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关键词
atopic dermatitis,dupilumab,ichthyosis,polarized microscopy,trichothiodystrophy
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