Preparation of Phenacyl Azides and Their Application Advances in Organic Synthesis

Phenacyl azides, a kind of crucial organic azide, serve as a valuable synthetic substrate in organic synthesis. They have extensive applications in constructing diverse nitrogen-containing compounds. Their straightforward synthetic methods, elevated reactivity and multiple reaction sites enable them to undergo reactions at a single site or simultaneously at multiple sites, resulting in a wide range of reaction types. Based on the significant progress made in organic synthesis in recent years, various preparation methods of phenacyl azides and research results classified according to specific reaction types are mainly reviewed. Representative examples and reaction mechanisms are discussed and analyzed.