Synthesis of 1-[ω-(bromophenoxy)alkyl]-3-naphthalenylmethyl derivatives of uracil and their analogues as probable inhibitors of human cytomegalovirus replication

A new series of 1-[ω-(bromophenoxy) has been synthesizedalkyl]-uracil derivatives containing naphthalene-1-yl-, naphthalene-2-yl-, 1-brominaphthalene-2-ilmethyl, benzyl and anthracene-9-ilmethyl fragments in position 3 of uracil. Antiviral properties of synthesized compounds against human cytomegalovirus were studied. It was found that the compound, which has a bridge consisting of five methylene groups, has high anti-cytomegalovirus activity in vitro. uracil