Development of Heart Simulator and Analysis of Valve Dysfunction in Tricuspid Regurgitation
APPLIED SCIENCES-BASEL(2024)
Abstract
Featured Application This work specifically applies to the development and validation of a cardiac simulation model that will facilitate the understanding of and mitigate tricuspid regurgitation (TR). The model employs diagnostic tools and a computational analysis to identify the medical conditions under which TR occurs and assesses the efficacy of potential interventions, notably the Pivot-TR device, in restoring normal heart valve function.Abstract Tricuspid regurgitation (TR) resulting from valve abnormalities necessitates precise diagnostic tools and interventions. We employed a simulated heart movement device to examine the performance of heart valve functions and analyzed internal pressure changes to provide a quantitative guide for TR treatment. We developed a simulator capable of replicating the flow profile, mimicking natural heart movements, with sensors installed for measuring internal pressure changes. We conducted an ex vivo experiment on a porcine heart to assess tricuspid valve functionality. An endoscope was installed, with a sensor and endoscopic images to detect abnormalities. TR became evident when the heart rate spectrum exceeded an average of 85.2 bpm (standard deviation, 1.3 bpm) and showed an amplitude higher than an average of 12.3 mmHg (standard deviation, 3.2 mmHg). This critical threshold consistently indicated TR onset. The application of the Pivot-TR attenuated this specific spectral area. We confirmed TR disappearance by reducing the intensity of the Tricuspid Regurgitation Generator or employing the Pivot-TR. The Pivot-TR's ability to attenuate specific spectral areas associated with TR onset and its effectiveness in restoring normal heart functionality has implications for managing and treating TR, particularly that resulting from age-related structural changes in the heart.
MoreTranslated text
Key words
simulation,tricuspid regurgitation,tricuspid valve,Short-Time Fourier Transform (STFT) analysis,Pivot-TR device
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined