Research on particle separation microfluidic chip based on standing surface acoustic wave

Abstract Microparticle and cell separation is a key process in the study of cell properties, clinical diagnosis and disease treatment. In this paper, a particle separation method based on the combination of surface acoustic wave and microfluidic technology is proposed, which uses standing surface acoustic wave to achieve the separating of polystyrene microparticles of different sizes twice in a continuous flow. Through numerical simulation of the device model and particle trajectory simulation, the optimum particle separation parameters were determined. The particle separation microfluidic chip has successfully realized the particle separation. The separation yield of 5 μm particles is about 92.1%. The separation rate of 1 μm particles is about 83.3%.