Insight into the structural characteristics of self-assembled liposome with epigallocatechin gallate/alcohol dehydrogenase
Colloids and Surfaces B: Biointerfaces(2024)
Abstract
In this study, the encapsulation and structural characteristics of the self-assembled liposome formed by epigallocatechin gallate (EGCG) and alcohol dehydrogenase (ADH) were studied. According to the results, EGCG significantly increased the catalytic activity of ADH with a 33.33% activation rate and the liposomes were able to entrap EGCG-ADH with an effectiveness of 88.94%. The self-assembled monolayers had nanometer-sized particles, and the excellent self-assembled system was demonstrated by the low PDI value and high surface absolute potential. The scanning electron microscope showed that the self-assembled liposome was honeycomb, groove-shaped, and rough. The spectroscopic results showed that EGCG-ADH complex was formed through hydrogen bond, which changed the secondary structure of the liposome, and verified EGCG-ADH liposome system was successfully prepared. In vitro digestion experiments showed that the gastrointestinal tolerance and antioxidant activity of EGCG-ADH liposomes were significantly higher than those of free EGCG-ADH.
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Key words
Structural characteristics,Alcohol dehydrogenase,Epigallocatechin gallate,Self-assembly,Liposomes
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