Efficient Radiolabeling of Proteins and Antibodies Via Maleamate-Cysteine Bioconjugation.
ACS MEDICINAL CHEMISTRY LETTERS(2024)
Abstract
The study introduces a novel maleamate-based prosthetic group specifically designed for efficient, site-specific radioiodination of biomolecules that contain or are modified with cysteine residues. This strategy is a compelling alternative to the conventional maleimide-based approach, demonstrating outstanding attributes such as high radiochemical yield, rapid reaction kinetics, applicability in aqueous media at neutral pH, and exceptional stability under a competitive environment.
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Key words
Thiol,Radiolabeling,SPECT,Bioconjugation,Radioiodination,Theranostics
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