A targetable receptor-binding site on PfCyRPA to aid in the fight against malaria

Trends in Parasitology（2024）

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摘要

Recently, Day et al. identified a receptor-binding site on the malaria parasite protein PfCyRPA that binds the host sugar Neu5Ac, and they found that disrupting this interaction impedes parasite growth. A map of the receptor-binding site identifies an attractive target for antimalarial vaccines and therapeutics.

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CyRPA,glycan,Neu5Ac,mAb,vaccine,malaria

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