Pharmacokinetic Study of Tilianin After Oral Administration in Wistar Rats by HPLC

Tilianin was obtained from the medicinal plant Agastache mexicana (Kunth) Lint Epling, Lamiaceae, a compound that is candidate to develop new multitarget drug for the treatment of metabolic syndrome–related diseases. The main aim of this work is to determine the pharmacokinetic parameters of tilianin after oral administration in Wistar rats to clarify its absorption pattern, distribution, metabolism, excretion, and permeability. A validated sensitive, selective, and reproducible high-performance liquid chromatography method was developed: r2 = 0.9992, 5.8 min of retention time, recovery of 100.2