Is MASLD lost in translation in mice?
Trends in Endocrinology & Metabolism(2024)
Abstract
Lack of preclinical model translation is often blamed for failed drug development. Here we discuss mouse models within the context of human steatotic liver disease (SLD). Variables such as aging and non-food hepatic stressors are often ignored but could explain challenges in reproducing the human disease in a laboratory.
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Key words
NAFLD,NASH,diet,preclinical models
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