Expedient Synthesis of gem-CF2-2H-Thiophenes from Enaminothiones
Synlett(2024)
Abstract
AbstractAn expedient and easy-to-handle synthetic platform has been established for the constructing of 2H-thiophenes carrying fluorine atoms through [4+1] cyclization of enaminothiones with fluorinated carbene precursors. This simple reaction system is well compatible with a wide range of substrates under completely metal-free conditions. The resulting 2H-thiophenes can undergo further late-stage modifications to yield a wide range of fluorine-substituted heterocycles.
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