Successful rescue TNF-α blocking for Mycobacterium genavense – related immune reconstitution inflammatory syndrome: a case report

Hugo Bes-Berlandier,Margaux Garzaro,Claire Rouzaud, Sylvain Bodard,Emmanuelle Bille, Maxence Ficheux,Dominique Cazals-Hatem, Nicolas Veziris, Fanny Lanternier,Olivier Lortholary

Heliyon（2024）

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摘要

Immune reconstitution inflammatory syndrome (IRIS) has been reported in immunocompromised patients with disseminated Mycobacterium genavense. Management relies on high-dose corticosteroids.We describe two cases of late-onset corticosteroid-refractory IRIS related to disseminated infection in a HIV-positive patient and a renal transplant patient who had a favorable outcome with a monoclonal TNF-α blocker.

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关键词

mycobacterium genavense,IRIS,monoclonal anti-TNF-α antibody,Infliximab,case report

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