Placenta-specific protein 1 (PLAC1) expression is significantly down-regulated in preeclampsia via a hypoxia-mediated mechanism.

Eric J Devor,Donna A Santillan,Akshaya Warrier,Sabrina M Scroggins,Mark K Santillan

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians（2022）

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摘要

We confirm that PLAC1 transcription is suppressed in the placentae of women affected by preeclampsia. We further demonstrate that this suppression is driven through the P2 or proximal PLAC1 promoter. This demonstration led to the identification of the MED1-TRAP cofactor complex as the hypoxia-sensitive driver.

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关键词

Preeclampsia placental dysfunction,dimethyloxaloylglycine (DMOG),hypoxia,mediator complex subunit 1 (MED1),placenta-specific protein 1 (PLAC1)

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