Artificial Intelligence Based Screening for Cardiomyopathy in an Obstetric Population: A Pilot Study
Cardiovascular Digital Health Journal(2024)
Abstract
Background
Cardiomyopathy is a leading cause of pregnancy related mortality and the number one cause of death in the late postpartum period. Delays in diagnosis is associated with severe adverse outcomes.
Objective
To evaluate the performance of an artificial intelligence enhanced electrocardiogram (AI-ECG) and AI-enabled digital stethoscope to detect left ventricular systolic dysfunction in an obstetric population.
Methods
We conducted a single arm prospective study of pregnant and postpartum women enrolled at 3 sites between October 28, 2021, and October 27, 2022. Study participants completed a standard 12-lead ECG, digital stethoscope ECG and phonocardiogram recordings, and a transthoracic echocardiogram within 24 hours. Diagnostic performance was evaluated using the area under the curve (AUC).
Results
One hundred women were included in the final analysis. The median age was 31 years (Q1: 27, Q3: 34). Thirty-eight percent identified as non-Hispanic White, 32% as non-Hispanic Black, and 21% as Hispanic. Five percent and 6% had LVEF <45% and <50% respectively. The AI-ECG model had near perfect classification performance (AUC: 1.0, 100% sensitivity; 99-100% specificity) for detection of cardiomyopathy at both LVEF categories. The AI-enabled digital stethoscope had an AUC of 0.98 (95% CI: 0.95, 1.00) and 0.97 (95% CI: 0.93, 1.00), for detection of LVEF <45% and <50% respectively with 100% sensitivity and 90% specificity.
Conclusion
We demonstrate an AI-ECG and AI-enabled digital stethoscope were effective for detecting cardiac dysfunction in an obstetric population. Larger studies, including an evaluation of the impact of screening on clinical outcomes, are essential next steps.
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Key words
Cardiomyopathies,ECG,Heart Failure,Obstetrics,Pregnancy,Postpartum
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