Association of comprehensive geriatric assessment with multidisciplinary treatment decision and adherence in elderly breast cancer patients

Abstract Purpose To assess the association of comprehensive geriatric assessments (CGA) and multidisciplinary team (MDT) treatment decision and adherence in elderly breast cancer patients. Methods Aged ≥ 60 patients were prospectively enrolled between June 2019 and January 2020. CGA was surveyed by 9 questionnaires before breast cancer surgery. Adjuvant treatment decisions were made by MDT discussion. Factors associated with adjuvant treatment decision were analyzed. Patients’ adherence to MDT decision according to CGA were also analyzed. Results A total of 211 patients were included: 87 (41.2%), 102 (48.3%), and 22 (10.4%) patients with age between 60–69, 70–79, and over 80, respectively. Patients with lower scores of VES-13 (95.7% vs 77.8%, P = 0.021) and higher scores of BI (96.7% vs 75%, P = 0.003) were more likely to be recommended with adjuvant radiotherapy. Rates of adjuvant chemotherapy recommendation was also higher for patients with lower VES score (46.8% vs 21.1%, P = 0.004) and higher BI score (45.6% vs 27.5%, P = 0.037). Adherence to adjuvant chemotherapy recommendation was found better in patients with fitter scores of CCI-adjustment (80.3% vs 53.8%, P = 0.038) Conclusion CGA was associated with adjuvant radiotherapy MDT decision, which also influenced the adherence to MDT adjuvant chemotherapy recommendation in elderly breast cancer patients.